There’s a lot going on whenever alcohol’s going through the body, so we’ll limit ourselves here to main systems only:

Liver. Since alcohol is so toxic, clearing it out of the system is a priority. And when the liver gets busy getting rid of alcohol, it gets behind in other functions, like maintaining stable blood-glucose levels to the brain. It takes a pounding in the process, too. Cirrhosis is a common result of long-term drinking, and one of the main killers of older drinkers.

Stomach. Alcohol irritates the stomach lining, and vomiting is a particularly visible result. Heavy drinking can lead to stomach problems and ulcers.

Central Nervous System. Alcohol depresses almost every brain function, from balance to breathing. And even though effects lessen as booze leaves the body, regular drinking raises tolerance, so that heavier drinkers can drink more without getting drunk. They do, that is, until liver damage reverses the process, which speeds up damage to the brain and the rest of the body.

Yeah, great